Exchange Rate Regimes and Economic Integration: The Case of the Accession Countries

Eu-Erweiterung, Wirtschaftsintegration, Wechselkurssystem, Europäische Wirtschafts-und Währungsunion, EU enlargement, Economic integration, Exchange-rate regime, European Economic and Monetary Union

Mechanismen meridionaler Transportprozesse im tropischen Atlantik

Meridional transport processes of water masses and tracers in the subtropical and tropical Atlantic are investigated using a regional eddy resolving model of the wind driven and thermohaline circulation. Analytical emphasis is on float simulations in the model which, complementary to Eulerian means, represent the Lagrangian view and give further insight into the spreading and pathways of characteristic water masses in this area. In the tropics and subtropics shallow 3-dimensional circulation cells are superimposed on the northward warm water transfer within the deep reaching thermohaline overturning cell (MOC) as part of the global ''Conveyor Belt''. Under present-day climate conditions the model shows that the equatorial thermocline is exclusively ventilated by subsurface flow within the tropical-subtropical cell (STC) of the South Atlantic. Only with a prescribed ''Conveyor-off''-Mode the STC of the North Atlantic contributes to this ventilation process with equal amounts. Throughout the year the interhemispheric transport of surface and central water masses of South Atlantic origin into the Caribbean Sea is dominated by zonal detours to the east as a consequence of the interplay of several retroflection events occuring in the North Atlantic. The eulerian mean flow field in the deep layer postulates the interhemispheric mass transport into the South Atlantic to be confined entirely to the western boundary, whereas Lagrangian means indicate intermittent eastward excursions along the equator, related to seasonally alternating zonal currents due to long Rossby waves. It was suggested that the observed characteristic eastward maximum of tracer concentrations along the equator is a consequence of rectifying effects of single or interacting equatorial waves. The model does not validate this hypothesis. The response to transport anomalies of subpolar origin and long periodicity is subject to different time-scales in both hemispheres. The fast response is confined to the northern hemisphere and dominates the first two years because of the mediating waves which at first propagate only around the North Atlantic basin. After 8 to 10 years the changes in the overturning are not restricted to the North anymore but are apparent in both hemispheres. (orig.)SIGLEAvailable from TIB Hannover: RN 3292(324) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekDEGerman

A critical evaluation of decadal solar cycle imprints in the MiKlip historical ensemble simulations

Studies concerning solar–terrestrial connections over the last decades claim to have found evidence that the quasi-decadal solar cycle can have an influence on the dynamics in the middle atmosphere in the Northern Hemisphere (NH) during the winter season. It has been argued that feedbacks between the intensity of the UV part of the solar spectrum and low-latitude stratospheric ozone may produce anomalies in meridional temperature gradients which have the potential to alter the zonal-mean flow in middle to high latitudes. Interactions between the zonal wind and planetary waves can lead to a downward propagation of the anomalies, produced in the middle atmosphere, down to the troposphere. More recently, it has been proposed that top-down-initiated decadal solar signals might modulate surface climate and synchronize the North Atlantic Oscillation. A realistic representation of the solar cycle in climate models was suggested to significantly enhance decadal prediction skill. These conclusions have been debated controversial since then due to the lack of realistic decadal prediction model setups and more extensive analysis. In this paper we aim for an objective and improved evaluation of possible solar imprints from the middle atmosphere to the surface and with that from head to toe. Thus, we analyze model output from historical ensemble simulations conducted with the state-of-the-art Max Planck Institute for Meteorology Earth System Model in high-resolution configuration (MPI-ESM-HR). The target of these simulations was to isolate the most crucial model physics to foster basic research on decadal climate prediction and to develop an operational ensemble decadal prediction system within the “Mittelfristige Klimaprognose” (MiKlip) framework. Based on correlations and multiple linear regression analysis we show that the MPI-ESM-HR simulates a realistic, statistically significant and robust shortwave heating rate and temperature response at the tropical stratopause, in good agreement with existing studies. However, the dynamical response to this initial radiative signal in the NH during the boreal winter season is weak. We find a slight strengthening of the polar vortex in midwinter during solar maximum conditions in the ensemble mean, which is consistent with the so-called “top-down” mechanism. The individual ensemble members, however, show a large spread in the dynamical response with opposite signs in response to the solar cycle, which might be a result of the large overall internal variability compensating for rather small solar imprints. We also analyze the possible surface responses to the 11-year solar cycle and review the proposed synchronization between the solar forcing and the North Atlantic Oscillation. We find that the simulated westerly wind anomalies in the lower troposphere, as well as the anomalies in the mean sea level pressure, are most likely independent from the timing of the solar signal in the middle atmosphere and the alleged top-down influences. The pattern rather reflects the decadal internal variability in the troposphere, mimicking positive and negative phases of the Arctic and North Atlantic oscillations throughout the year sporadically, which is then assigned to the solar predictor time series without any plausible physical connection and sound solar contribution. Finally, by applying lead–lag correlations, we find that the proposed synchronization between the solar cycle and the decadal component of the North Atlantic Oscillation might rather be a statistical artifact, affected for example by the internal decadal variability in the ocean, than a plausible physical connection between the UV solar forcing and quasi-decadal variations in the troposphere

Porcine Colostrum Protects the IPEC-J2 Cells and Piglet Colon Epithelium against Clostridioides (syn. Clostridium) difficile Toxin-Induced Effects

Clostridioides difficile toxins are one of the main causative agents for the clinical symptoms observed during C. difficile infection in piglets. Porcine milk has been shown to strengthen the epithelial barrier function in the piglet’s intestine and may have the potential to neutralise clostridial toxins. We hypothesised that porcine colostrum exerts protective effects against those toxins in the IPEC-J2 cells and in the colon epithelium of healthy piglets. The IPEC-J2 cells were treated with either the toxins or porcine colostrum or their combination. Analyses included measurement of trans-epithelial electrical resistance (TEER), cell viability using propidium iodide by flow cytometry, gene expression of tight junction (TJ) proteins and immune markers, immunofluorescence (IF) histology of the cytoskeleton and a TJ protein assessment. Colon tissue explants from one- and two-week-old suckling piglets and from five-week-old weaned piglets were treated with C. difficile toxins in Ussing chamber assays to assess the permeability to macromolecules (FITC-dextran, HRP), followed by analysis of gene expression of TJ proteins and immune markers. Toxins decreased viability and integrity of IPEC-J2 cells in a time-dependent manner. Porcine colostrum exerted a protective effect against toxins as indicated by TEER and IF in IPEC-J2 cells. Toxins tended to increase paracellular permeability to macromolecules in colon tissues of two-week-old piglets and downregulated gene expression of occludin in colon tissues of five-week-old piglets (p = 0.05). Porcine milk including colostrum, besides other maternal factors, may be one of the important determinants of early immune programming towards protection from C. difficile infections in the offspring

Replacement of hematopoietic system by allogeneic stem cell transplantation in myelofibrosis patients induces rapid regression of bone marrow fibrosis

Bone marrow fibrosis is a hallmark of primary and post ET/PV myelofibrosis. To investigated the impact of replacement of the hematopoietic system in myelofibrosis patients by allogeneic stem cell transplantation on bone marrow fibrosis, we studied bone marrow fibrosis on bone marrow samples from 24 patients with myelofibrosis before and after dose-reduced conditioning followed by allogeneic stem cell transplantation from related or unrelated donor. Using the European Consensus on Grading Bone Marrow Fibrosis, before allografting all patients had advanced fibrosis MF-2 (n = 13) or MF-3 (n = 11). After transplantation, a complete (MF-0) or nearly complete (MF-1) regression of bone marrow fibrosis was seen in 59 % at day +100, in 90 % at day +180, and in 100 % at day +360. No correlation between occurrence of acute graft-versus-host disease, and fibrosis regression on day +180 was seen. We conclude that dose-reduced conditioning, followed by allogeneic stem cell transplantation, resulted in a rapid resolution of bone-marrow fibrosis suggesting the bone marrow fibrogenesis is a highly dynamic rather than static process in patients with myelofibrosis

Prevalence and Infant Mortality of Major Congenital Malformations Stratified by Birthweight

Background: Low birthweight and major congenital malformations (MCMs) are key causes of infant mortality. Objectives: The aim of this study was to explore the prevalence of MCMs in infants with low and very low birthweight and analyze the impact of MCMs and birthweight on infant mortality. Methods: We determined prevalence and infant mortality of 28 life-threatening MCMs in very-low-birthweight (75% (10,316) had severe congenital heart disease. The prevalence (per 10,000) of any/cardiac MCM was increased in VLBW (286/176) and LBW (244/143), as compared to NBW infants (38/32). Infant mortality rates were significantly higher in infants with an MCM, as opposed to infants without an MCM, in each birthweight group (VLBW 28.5% vs. 11.5%, LBW 16.7% vs. 0.9%, and NBW 8.6% vs. 0.1%). For most MCMs, observed survival rates in VLBW and LBW infants were lower than expected, as calculated from survival rates of VLBW or LBW infants without an MCM, and NBW infants with an MCM. Conclusions: Infants with an MCM are more often born with LBW or VLBW, as opposed to infants without an MCM. Many MCMs carry significant excess mortality when occurring in VLBW or LBW infants

In vivo non-invasive staining-free visualization of dermal mast cells in healthy, allergy and mastocytosis humans using two-photon fluorescence lifetime imaging

Mast cells (MCs) are multifunctional cells of the immune system and are found in skin and all major tissues of the body. They contribute to the pathology of several diseases including urticaria, psoriasis, atopic dermatitis and mastocytosis where they are increased at lesional sites. Histomorphometric analysis of skin biopsies serves as a routine method for the assessment of MC numbers and their activation status, which comes with major limitations. As of now, non-invasive techniques to study MCs in vivo are not available. Here, we describe a label-free imaging technique to visualize MCs and their activation status in the human papillary dermis in vivo. This technique uses two-photon excited fluorescence lifetime imaging (TPE-FLIM) signatures, which are different for MCs and other dermal components. TPE-FLIM allows for the visualization and quantification of dermal MCs in healthy subjects and patients with skin diseases. Moreover, TPE-FLIM can differentiate between two MC populations in the papillary dermis in vivo—resting and activated MCs with a sensitivity of 0.81 and 0.87 and a specificity of 0.85 and 0.84, respectively. Results obtained on healthy volunteers and allergy and mastocytosis patients indicate the existence of other MC subpopulations within known resting and activated MC populations. The developed method may become an important tool for non-invasive in vivo diagnostics and therapy control in dermatology and immunology, which will help to better understand pathomechanisms involving MC accumulation, activation and degranulation and to characterize the effects of therapies that target MCs